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新药院学术报告 总34讲(2019年第13讲)——膦酸药物用于蛋白质脂酰化相关的病理研究

2019-06-04

报告题目:Selected aspects of protein lipidation associated with  pathological states; the potential of phosphonic acids as  therapeutics(膦酸药物用于蛋白质脂酰化相关的病理研究)

报告时间:524日(星期五)上午10:3011:30

报告地点:包玉书7号楼4412会议室

人:Katarzyna Błażewska  Assistant  Professor

人:倪锋 教授

报告人简介:

Katarzyna Blazewska  is an Assistant Professor at the Faculty of Chemistry of Lodz University of  Technology, Poland. She obtained her Ph.D. in Chemistry from the Lodz University  of Technology and did postdoctoral training at University of Southern  California, USA. She undertook scientific visits at the University of  Strasbourg, France, Boston College, US (as Fulbright scholar) and Imperial  Colleague of London, UK.
From the  beginning of her career, her research interests were focused on the synthesis  and potential applications of phosphonates and phosphonic acids. Currently she  concentrates on studies of Rab prenylation mediated by Rab GGTase, using  medicinal chemistry and chemical biology tools. Her research revolves around the  structure-activity studies, design of prodrug analogs, development of  photoaffinity probes for studies of ligand-enzyme interactions in the whole  proteome.


Prof.  Blazewska has received various grants (including Polish National Science Centre,  Polish Ministry of Science and Higher Education and Polish-US Fulbright  Commission grants) and published her work in Journal of Medical Chemistry,  Journal of Bone and Mineral Research, Chemical Communication, Molecular Cell  Biology, among the others. She published 25 scientific articles with cumulative  impact factor more than 90 points. Prof. Blazewska is expert in Horizon 2010 and  Polish National Science Centre grants, lecturer of Organic Chemistry,  Fundamentals of Drug Design; Prodrugs graduate courses. She co-organized  international meeting “Chemical Probes: exploring avenues for protein  investigation” and delivered invited talk at the conferences and partner  institutions.